Mitochondrial replacement therapy (MRT), also known as mitochondrial donation (MD), is promoted as an option to prevent transmission of mitochondrial disorders to offspring. Since its first reported use in humans, MRT has raised numerous ethical and medical concerns. This article will explore the technology behind MRT and arguments in favor of and opposing it, concluding that a response through the lens of Scripture promotes flourishing of individuals and families affected by mitochondrial disorders without sacrificing others in the process.